miR-21 regulates immunosuppression mediated by myeloid-derived suppressor cells by impairing RUNX1-YAP interaction in lung cancer

miR-21 regulates immunosuppression mediated by myeloid-derived suppressor cells by impairing RUNX1-YAP interaction in lung cancer

Abstract Background Myeloid-derived suppressor cells (MDSCs) are known suppressors of antitumor immunity and contribute to immunosuppressive microenvironment during tumor development including lung cancer. Accumulating evidence shows microRNAs (miRNAs) affect tumor-expanded MDSC accumulation and fun...

Full description

Bibliographic Details
Main Authors: Guangping Meng, Jinying Wei, Yanjun Wang, Danhua Qu, Jie Zhang
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Cancer Cell International
Subjects:
Lung cancer
microRNA-21
Runt-related transcription factor 1
Yes-associated Protein
Myeloid-derived suppressor cells
Immunosuppressive ability
Online Access:http://link.springer.com/article/10.1186/s12935-020-01555-7

Internet

http://link.springer.com/article/10.1186/s12935-020-01555-7

Similar Items