Alpha-mangostin induces endoplasmic reticulum stress and autophagy which count against fatty acid synthase inhibition mediated apoptosis in human breast cancer cells

Alpha-mangostin induces endoplasmic reticulum stress and autophagy which count against fatty acid synthase inhibition mediated apoptosis in human breast cancer cells

Abstract Background/aims One of the most important metabolic hallmarks of breast cancer cells is enhanced lipogenesis. Increasing evidences suggest that fatty acid synthase (FAS) plays an important role in human breast cancer. Previously we discovered that alpha-mangostin showed apoptotic effect on...

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Bibliographic Details
Main Authors: Wenyuan Huang, Yan Liang, Xiaofeng Ma
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Cancer Cell International
Subjects:
Fatty acid synthase
Alpha-mangostin
Inhibitor
Autophagy
Endoplasmic reticulum stress
Online Access:http://link.springer.com/article/10.1186/s12935-019-0869-z

Internet

http://link.springer.com/article/10.1186/s12935-019-0869-z

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