Rapamycin Improves Spatial Learning Deficits, Vulnerability to Alcohol Addiction and Altered Expression of the GluN2B Subunit of the NMDA Receptor in Adult Rats Exposed to Ethanol during the Neonatal Period

Rapamycin Improves Spatial Learning Deficits, Vulnerability to Alcohol Addiction and Altered Expression of the GluN2B Subunit of the NMDA Receptor in Adult Rats Exposed to Ethanol during the Neonatal Period

Ethanol exposure during pregnancy alters the mammalian target of rapamycin (mTOR) signaling pathway in the fetal brain. Hence, in adult rats exposed to ethanol during the neonatal period, we investigated the influence of rapamycin, an mTOR Complex 1 (mTORC1) inhibitor, on deficits in spatial memory...

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Bibliographic Details
Main Authors: Malgorzata Lopatynska-Mazurek, Anna Antolak, Pawel Grochecki, Ewa Gibula-Tarlowska, Anna Bodzon-Kulakowska, Joanna Listos, Ewa Kedzierska, Piotr Suder, Jerzy Silberring, Jolanta H. Kotlinska
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Biomolecules
Subjects:
rapamycin 1
spatial learning 2
reward 3
neonatal ethanol exposure 4
adult rats 5
Online Access:https://www.mdpi.com/2218-273X/11/5/650

Internet

https://www.mdpi.com/2218-273X/11/5/650

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