Tumor Suppressive Maspin-Sensitized Prostate Cancer to Drug Treatment Through Negative Regulating Androgen Receptor Expression

Tumor Suppressive Maspin-Sensitized Prostate Cancer to Drug Treatment Through Negative Regulating Androgen Receptor Expression

Overactivation of androgen receptor (AR)-mediated signal has been extensively implicated in prostate cancer (CaP) development, progression, and recurrence, which makes it an attractive therapeutic target. Meanwhile, as an endogenous inhibitor of histone deacetylase 1 (HDAC 1), tumor-suppressive mamm...

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Bibliographic Details
Main Authors: Sijie Tang, Xueqi Lian, Jiajia Jiang, Huiying Cheng, Jiaqian Guo, Can Huang, Hong Meng, Xiaohua Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
maspin
androgen receptor
HDAC inhibitor
chemotherapy
castration-resistant prostate cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.573820/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.573820/full

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