Structures of SHV-1 β-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation.

Structures of SHV-1 β-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation.

Bacterial β-lactamase enzymes are in large part responsible for the decreased ability of β-lactam antibiotics to combat infections. The inability to overcome β-lactamase mediated resistance spurred the development of inhibitors with penems and penam sulfones being amongst the most potent and broad s...

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Bibliographic Details
Main Authors: Wei Ke, Priyaranjan Pattanaik, Christopher R Bethel, Anjaneyulu Sheri, John D Buynak, Robert A Bonomo, Focco van den Akker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3493512?pdf=render

Internet

http://europepmc.org/articles/PMC3493512?pdf=render

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