MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia

MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia

Abstract Background In the extracellular environment, lysophosphatidic acid (LPA) species are generated via autotaxin (ATX)-mediated hydrolysis of lysophospholipid precursors. Members of the LPA family are potent lipid mediators transmitting signals via six different G protein-coupled LPA receptors...

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Bibliographic Details
Main Authors: Ioanna Plastira, Eva Bernhart, Lisha Joshi, Chintan N. Koyani, Heimo Strohmaier, Helga Reicher, Ernst Malle, Wolfgang Sattler
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Neuroinflammation
Subjects:
Bioactive lipids
JNK
p38
ERK1/2
Chemokines
Cytokines
Online Access:http://link.springer.com/article/10.1186/s12974-020-01809-1

Internet

http://link.springer.com/article/10.1186/s12974-020-01809-1

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