TRAF2 Is a Novel Ubiquitin E3 Ligase for the Na,K-ATPase β-Subunit That Drives Alveolar Epithelial Dysfunction in Hypercapnia

TRAF2 Is a Novel Ubiquitin E3 Ligase for the Na,K-ATPase β-Subunit That Drives Alveolar Epithelial Dysfunction in Hypercapnia

Several acute and chronic lung diseases are associated with alveolar hypoventilation leading to accumulation of CO2 (hypercapnia). The β-subunit of the Na,K-ATPase plays a pivotal role in maintaining epithelial integrity by functioning as a cell adhesion molecule and regulating cell surface stabilit...

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Bibliographic Details
Main Authors: Nieves M. Gabrielli, Luciana C. Mazzocchi, Vitalii Kryvenko, Khodr Tello, Susanne Herold, Rory E. Morty, Friedrich Grimminger, Laura A. Dada, Werner Seeger, Jacob I. Sznajder, István Vadász
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Na
K-ATPase β-subunit
carbon dioxide
ubiquitination
endocytosis
PKC-ζ
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.689983/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.689983/full

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