Endoplasmic Reticulum-Mitochondria Crosstalk and Beta-Cell Destruction in Type 1 Diabetes

Endoplasmic Reticulum-Mitochondria Crosstalk and Beta-Cell Destruction in Type 1 Diabetes

Beta-cell destruction in type 1 diabetes (T1D) results from the combined effect of inflammation and recurrent autoimmunity. In response to inflammatory signals, beta-cells engage adaptive mechanisms where the endoplasmic reticulum (ER) and mitochondria act in concert to restore cellular homeostasis....

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Bibliographic Details
Main Authors: Saurabh Vig, Joost M. Lambooij, Arnaud Zaldumbide, Bruno Guigas
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
endoplasmic reticulum
ER stress
mitochondria
Type 1 diabetes (T1D)
beta-cell
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.669492/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.669492/full

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