Adaptive Evolution of MERS-CoV to Species Variation in DPP4

Summary: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) likely originated in bats and passed to humans through dromedary camels; however, the genetic mechanisms underlying cross-species adaptation remain poorly understood. Variation in the host receptor, dipeptidyl peptidase 4 (DPP4), can b...

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Bibliographic Details
Main Authors: Michael Letko, Kerri Miazgowicz, Rebekah McMinn, Stephanie N. Seifert, Isabel Sola, Luis Enjuanes, Aaron Carmody, Neeltje van Doremalen, Vincent Munster
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718311483