Impaired spatial memory and enhanced long-term potentiation in mice with forebrain-specific ablation of the Stim genes

Impaired spatial memory and enhanced long-term potentiation in mice with forebrain-specific ablation of the Stim genes

Recent findings point to a central role of the endoplasmic reticulum resident STIM (Stromal Interaction Molecule) proteins in shaping the structure and function of excitatory synapses in the mammalian brain. The impact of the Stim genes on cognitive functions remains, however, poorly understood. To...

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Bibliographic Details
Main Authors: Gisela eGarcia-Alvarez, Mahesh Shivarama Shetty, Bo eLu, Kenrick An Fu Yap, Masatsugu eOh-Hora, Sreedharan eSajikumar, Zoe eBichler, Marc eFivaz
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Endoplasmic Reticulum
Long-Term Potentiation
AMPA receptor
spatial memory
PKA
excitatory synapse
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00180/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00180/full

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