High Concentration of Low-Density Lipoprotein Results in Disturbances in Mitochondrial Transcription and Functionality in Endothelial Cells

High Concentration of Low-Density Lipoprotein Results in Disturbances in Mitochondrial Transcription and Functionality in Endothelial Cells

Concentrations of low-density lipoprotein (LDL) above 0.8 mg/ml have been associated with increased risk for cardiovascular diseases and impaired endothelial functionality. Here, we demonstrate that high concentrations of LDL (1 mg/ml) decreased NOS3 protein and RNA levels in primary human endotheli...

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Bibliographic Details
Main Authors: Stefanie Gonnissen, Johannes Ptok, Christine Goy, Kirsten Jander, Philipp Jakobs, Olaf Eckermann, Wolfgang Kaisers, Florian von Ameln, Jörg Timm, Niloofar Ale-Agha, Judith Haendeler, Heiner Schaal, Joachim Altschmied
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2019/7976382

Internet

http://dx.doi.org/10.1155/2019/7976382

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