Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer.

Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer.

BACKGROUND:Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to current therapeutic approaches. Melanocytic transformation is thought to occur by sequential accumulation of genetic and molecular alterations able to activate the Ras/Raf/MEK/ERK (MAPK) and/or the PI3K/AKT...

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Bibliographic Details
Main Authors: Francesco Pappalardo, Giulia Russo, Saverio Candido, Marzio Pennisi, Salvatore Cavalieri, Santo Motta, James A McCubrey, Ferdinando Nicoletti, Massimo Libra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4807832?pdf=render

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http://europepmc.org/articles/PMC4807832?pdf=render

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