An 8-Hydroxy-Quinoline Derivative Protects Against Lipopolysaccharide-Induced Lethality in Endotoxemia by Inhibiting HMGB1-Mediated Caspase-11 Signaling

An 8-Hydroxy-Quinoline Derivative Protects Against Lipopolysaccharide-Induced Lethality in Endotoxemia by Inhibiting HMGB1-Mediated Caspase-11 Signaling

Sepsis, an inflammatory syndrome secondary to infection, is the leading cause of in-hospital lethality. It is evidenced that LPS, the major pathological component of the Gram-negative bacteria membrane, predominantly contributes to the pathogenesis of sepsis. Cytoplasmic lipopolysaccharide (LPS) can...

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Bibliographic Details
Main Authors: Xiangyu Wang, Jian Shi, Zhaozheng Li, Ling Li, Rui Zhang, Yang Bai, Junmei Li, Fang Liang, Yiting Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
caspase-11
pyroptosis
inflammasome
phenotypic screening
sepsis
HMGB1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.673818/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.673818/full

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