NCS 613, a Potent PDE4 Inhibitor, Displays Anti-Inflammatory and Anti-Proliferative Properties on A549 Lung Epithelial Cells and Human Lung Adenocarcinoma Explants

NCS 613, a Potent PDE4 Inhibitor, Displays Anti-Inflammatory and Anti-Proliferative Properties on A549 Lung Epithelial Cells and Human Lung Adenocarcinoma Explants

Chronic inflammation is a deleterious process occurring in several pulmonary diseases; it is a driving force promoting tumorigenesis. By regulating local cyclic nucleotide concentration, cyclic nucleotide phosphodiesterases (PDE) govern important biological processes, including inflammation and prol...

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Bibliographic Details
Main Authors: Issaka Yougbare, Lazare Belemnaba, Caroline Morin, Abdurazzag Abusnina, Yannick F. Senouvo, Thérèse Keravis, Claire Lugnier, Eric Rousseau
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
PDE4 inhibitor
cAMP signaling
inflammation
proliferation
human lung adenocarcinoma
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01266/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01266/full

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