A minimal model for structure, dynamics, and tension of monolayered cell colonies

A minimal model for structure, dynamics, and tension of monolayered cell colonies

Cells are in constant movement inside tissues, but often remain cohesive nevertheless, i.e., single cells do not escape from the colony edges. Using an active Brownian-particle model with attraction, in this paper the authors develop an interaction potential that reproduces experimental observations...

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Bibliographic Details
Main Authors: Debarati Sarkar, Gerhard Gompper, Jens Elgeti
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Communications Physics
Online Access:https://doi.org/10.1038/s42005-020-00515-x
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spelling doaj-be1ea23d48c743c5b67f6494bec3f0622021-03-11T11:52:26ZengNature Publishing GroupCommunications Physics2399-36502021-02-01411810.1038/s42005-020-00515-xA minimal model for structure, dynamics, and tension of monolayered cell coloniesDebarati Sarkar0Gerhard Gompper1Jens Elgeti2Theoretical Physics of Living Matter, Institute of Biological Information Processing and Institute for Advanced Simulation, Forschungszentrum JülichTheoretical Physics of Living Matter, Institute of Biological Information Processing and Institute for Advanced Simulation, Forschungszentrum JülichTheoretical Physics of Living Matter, Institute of Biological Information Processing and Institute for Advanced Simulation, Forschungszentrum JülichCells are in constant movement inside tissues, but often remain cohesive nevertheless, i.e., single cells do not escape from the colony edges. Using an active Brownian-particle model with attraction, in this paper the authors develop an interaction potential that reproduces experimental observations describing the motion of epithelial sheets under different conditions.https://doi.org/10.1038/s42005-020-00515-x
collection DOAJ
language English
format Article
sources DOAJ
author Debarati Sarkar
Gerhard Gompper
Jens Elgeti
spellingShingle Debarati Sarkar
Gerhard Gompper
Jens Elgeti
A minimal model for structure, dynamics, and tension of monolayered cell colonies
Communications Physics
author_facet Debarati Sarkar
Gerhard Gompper
Jens Elgeti
author_sort Debarati Sarkar
title A minimal model for structure, dynamics, and tension of monolayered cell colonies
title_short A minimal model for structure, dynamics, and tension of monolayered cell colonies
title_full A minimal model for structure, dynamics, and tension of monolayered cell colonies
title_fullStr A minimal model for structure, dynamics, and tension of monolayered cell colonies
title_full_unstemmed A minimal model for structure, dynamics, and tension of monolayered cell colonies
title_sort minimal model for structure, dynamics, and tension of monolayered cell colonies
publisher Nature Publishing Group
series Communications Physics
issn 2399-3650
publishDate 2021-02-01
description Cells are in constant movement inside tissues, but often remain cohesive nevertheless, i.e., single cells do not escape from the colony edges. Using an active Brownian-particle model with attraction, in this paper the authors develop an interaction potential that reproduces experimental observations describing the motion of epithelial sheets under different conditions.
url https://doi.org/10.1038/s42005-020-00515-x
work_keys_str_mv AT debaratisarkar aminimalmodelforstructuredynamicsandtensionofmonolayeredcellcolonies
AT gerhardgompper aminimalmodelforstructuredynamicsandtensionofmonolayeredcellcolonies
AT jenselgeti aminimalmodelforstructuredynamicsandtensionofmonolayeredcellcolonies
AT debaratisarkar minimalmodelforstructuredynamicsandtensionofmonolayeredcellcolonies
AT gerhardgompper minimalmodelforstructuredynamicsandtensionofmonolayeredcellcolonies
AT jenselgeti minimalmodelforstructuredynamicsandtensionofmonolayeredcellcolonies
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