The COX-2 Selective Blocker Etodolac Inhibits TNFα-Induced Apoptosis in Isolated Rabbit Articular Chondrocytes

The COX-2 Selective Blocker Etodolac Inhibits TNFα-Induced Apoptosis in Isolated Rabbit Articular Chondrocytes

Chondrocyte apoptosis contributes to the disruption of cartilage integrity in osteoarthritis (OA). Recently, we reported that activation of volume-sensitive Cl− current (ICl,vol) mediates cell shrinkage, triggering apoptosis in rabbit articular chondrocytes. A cyclooxygenase (COX) blocker is frequen...

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Bibliographic Details
Main Authors: Hiroshi Matsuura, Noriaki Okumura, Tsutomu Maeda, Shinji Imai, Futoshi Toyoda, Mitsuhiko Kubo, Kousuke Kumagai, Yoshitaka Matsusue
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:International Journal of Molecular Sciences
Subjects:
chondrocyte
apoptosis
TNFα
COX-2
osteoarthritis
Online Access:http://www.mdpi.com/1422-0067/14/10/19705

Internet

http://www.mdpi.com/1422-0067/14/10/19705

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