Theoretical Studies on Catalysis Mechanisms of Serum Paraoxonase 1 and Phosphotriesterase Diisopropyl Fluorophosphatase Suggest the Alteration of Substrate Preference from Paraoxonase to DFP

Theoretical Studies on Catalysis Mechanisms of Serum Paraoxonase 1 and Phosphotriesterase Diisopropyl Fluorophosphatase Suggest the Alteration of Substrate Preference from Paraoxonase to DFP

The calcium-dependent β-propeller proteins mammalian serum paraoxonase 1 (PON1) and phosphotriesterase diisopropyl fluorophosphatase (DFPase) catalyze the hydrolysis of organophosphorus compounds and enhance hydrolysis of various nerve agents. In the present work, the phosphotriesterase act...

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Bibliographic Details
Main Authors: Hao Zhang, Ling Yang, Ying-Ying Ma, Chaoyuan Zhu, Shenghsien Lin, Rong-Zhen Liao
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
enzyme evolution
hydrolysis
β-propeller protein
plasticity
reaction mechanism
Online Access:http://www.mdpi.com/1420-3049/23/7/1660

Internet

http://www.mdpi.com/1420-3049/23/7/1660

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