Hepatitis B Virus X Protein Inhibits Tumor Suppressor miR-205 through Inducing Hypermethylation of miR-205 Promoter to Enhance Carcinogenesis

Hepatitis B Virus X Protein Inhibits Tumor Suppressor miR-205 through Inducing Hypermethylation of miR-205 Promoter to Enhance Carcinogenesis

The infection of hepatitis B virus (HBV) is closely associated with the development of hepatocellular carcinoma (HCC), in which HBV X protein (HBx) plays crucial roles. MicroRNAs are involved in diverse biologic functions and in carcinogenesis by regulating gene expression. In the present study, we...

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Bibliographic Details
Main Authors: Tao Zhang, Junping Zhang, Ming Cui, Fabao Liu, Xiaona You, Yumei Du, Yuen Gao, Shuai Zhang, Zhanping Lu, Lihong Ye, Xiaodong Zhang
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558613800899

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http://www.sciencedirect.com/science/article/pii/S1476558613800899

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