Synthesis, Characterization, and Anticancer Activities Evaluation of Compounds Derived from 3,4-Dihydropyrimidin-2(1H)-one

Synthesis, Characterization, and Anticancer Activities Evaluation of Compounds Derived from 3,4-Dihydropyrimidin-2(1H)-one

3,4-dihydropyrimidin-2(1H)-one compounds (DHPMs) possess extensive biological activities and are mainly prepared via Biginelli reaction and N-alkylation. In the present study, selective alkylation of N1 was investigated by using tetrabutylammonium hydroxide. In vitro cytotoxicity study on all synthe...

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Bibliographic Details
Main Authors: Ye Liu, Jiaqi Liu, Renmei Zhang, Yan Guo, Hongbo Wang, Qingguo Meng, Yuan Sun, Zongliang Liu
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
3,4-dihydropyrimidin-2(1H)-ones
N1-alkylation
structure-activity relationship
in vivo experiments
anticancer activities
Online Access:http://www.mdpi.com/1420-3049/24/5/891

Internet

http://www.mdpi.com/1420-3049/24/5/891

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