mRNA Structural constraints on EBNA1 synthesis impact on in vivo antigen presentation and early priming of CD8+ T cells.

mRNA Structural constraints on EBNA1 synthesis impact on in vivo antigen presentation and early priming of CD8+ T cells.

Recent studies have shown that virally encoded mRNA sequences of genome maintenance proteins from herpesviruses contain clusters of unusual structural elements, G-quadruplexes, which modulate viral protein synthesis. Destabilization of these G-quadruplexes can override the inhibitory effect on self-...

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Bibliographic Details
Main Authors: Judy T Tellam, Jie Zhong, Lea Lekieffre, Purnima Bhat, Michelle Martinez, Nathan P Croft, Warren Kaplan, Ross L Tellam, Rajiv Khanna
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4192603?pdf=render

Internet

http://europepmc.org/articles/PMC4192603?pdf=render

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