Impacts of drug resistance mutations on the structural asymmetry of the HIV-2 protease

Impacts of drug resistance mutations on the structural asymmetry of the HIV-2 protease

Abstract Background Drug resistance is a severe problem in HIV treatment. HIV protease is a common target for the design of new drugs for treating HIV infection. Previous studies have shown that the crystallographic structures of the HIV-2 protease (PR2) in bound and unbound forms exhibit structural...

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Bibliographic Details
Main Authors: Pierre Laville, Sandrine Fartek, Natacha Cerisier, Delphine Flatters, Michel Petitjean, Leslie Regad
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Molecular and Cell Biology
Subjects:
HIV-2 protease
Drug-resistance mutations
Structural asymmetry
Structural alphabet
Online Access:http://link.springer.com/article/10.1186/s12860-020-00290-1

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http://link.springer.com/article/10.1186/s12860-020-00290-1

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