Immunomodulatory Effects of Hydroxychloroquine and Chloroquine in Viral Infections and Their Potential Application in Retinal Gene Therapy

Effective treatment of retinal diseases with adeno-associated virus (AAV)-mediated gene therapy is highly dependent on the proportion of successfully transduced cells. However, due to inflammatory reactions at high vector doses, adjunctive treatment may be necessary to enhance the therapeutic outcom...

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Bibliographic Details
Main Authors: Laurel C. Chandler, Imran H. Yusuf, Michelle E. McClements, Alun R. Barnard, Robert E. MacLaren, Kanmin Xue
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
AAV
Online Access:https://www.mdpi.com/1422-0067/21/14/4972