Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy

Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy

γ-Glutamylcyclotransferase (GGCT), which is one of the major enzymes involved in glutathione metabolism, is upregulated in a wide range of cancers—glioma, breast, lung, esophageal, gastric, colorectal, urinary bladder, prostate, cervical, ovarian cancers and osteosarcoma&mdas...

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Bibliographic Details
Main Authors: Susumu Kageyama, Hiromi Ii, Keiko Taniguchi, Shigehisa Kubota, Tetsuya Yoshida, Takahiro Isono, Tokuhiro Chano, Taku Yoshiya, Kosei Ito, Tatsuhiro Yoshiki, Akihiro Kawauchi, Susumu Nakata
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
GGCT
C7orf24
cancer
cellular senescence
autophagy
Online Access:http://www.mdpi.com/1422-0067/19/7/2054

Internet

http://www.mdpi.com/1422-0067/19/7/2054

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