Hypertonic sodium lactate improves microcirculation, cardiac function, and inflammation in a rat model of sepsis

Hypertonic sodium lactate improves microcirculation, cardiac function, and inflammation in a rat model of sepsis

Abstract Background Hypertonic sodium lactate (HSL) may be of interest during inflammation. We aimed to evaluate its effects during experimental sepsis in rats (cecal ligation and puncture (CLP)). Methods Three groups were analyzed (n = 10/group): sham, CLP-NaCl 0.9%, and CLP-HSL (2.5 mL/kg/h of flu...

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Bibliographic Details
Main Authors: Emmanuel Besnier, David Coquerel, Geoffrey Kouadri, Thomas Clavier, Raphael Favory, Thibault Duburcq, Olivier Lesur, Soumeya Bekri, Vincent Richard, Paul Mulder, Fabienne Tamion
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Critical Care
Subjects:
Sodium lactate
Sepsis
Metabolism
Microcirculation
Heart failure
Online Access:http://link.springer.com/article/10.1186/s13054-020-03083-2

Internet

http://link.springer.com/article/10.1186/s13054-020-03083-2

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