Potential of PEGylated toll-like receptor 7 ligands for controlling inflammation and functional changes in mouse models of asthma and silicosis

Potential of PEGylated toll-like receptor 7 ligands for controlling inflammation and functional changes in mouse models of asthma and silicosis

Prior investigations show that signaling activation through pattern recognition receptors can directly impact a number of inflammatory lung diseases. While toll-like receptor (TLR) 7 agonists have raised interest for their ability to inhibit allergen-induced pathological changes in experimental asth...

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Bibliographic Details
Main Authors: Tatiana Paula Teixeira Ferreira, Livia Lacerda Mariano, Roberta Ghilosso Bortolini, Ana Carolina Santos Arantes, Andrey eFernandes, Michelle eBerni, Valentina eCecchinato, Mariagrazia eUguccioni, Roberto eMaj, Alcide eBarberis, Patricia Machado Rodrigues Silva, Marco Aurélio Martins
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Immunology
Subjects:
Asthma
Silicosis
animal model
TLR7
acute lung injury (ALI)
PEGylated ligands
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00095/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00095/full

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