A p38 MAPK-mediated alteration of COX-2/PGE2 regulates immunomodulatory properties in human mesenchymal stem cell aging.

A p38 MAPK-mediated alteration of COX-2/PGE2 regulates immunomodulatory properties in human mesenchymal stem cell aging.

Because human mesenchymal stem cells (hMSC) have profound immunomodulatory effects, many attempts have been made to use hMSCs in preclinical and clinical trials. For hMSCs to be used in therapy, a large population of hMSCs must be generated by in vitro expansion. However, the immunomodulatory change...

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Bibliographic Details
Main Authors: Kyung-Rok Yu, Jin Young Lee, Hyung-Sik Kim, In-Sun Hong, Soon Won Choi, Yoojin Seo, Insung Kang, Jae-Jun Kim, Byung-Chul Lee, SeungHee Lee, Andreas Kurtz, Kwang-Won Seo, Kyung-Sun Kang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4121064?pdf=render

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http://europepmc.org/articles/PMC4121064?pdf=render

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