Disulfiram/copper markedly induced myeloma cell apoptosis through activation of JNK and intrinsic and extrinsic apoptosis pathways

Disulfiram/copper markedly induced myeloma cell apoptosis through activation of JNK and intrinsic and extrinsic apoptosis pathways

Disulfiram (DSF) is an FDA approved anti-alcoholism drug in use for more than 60 years. Recently, antitumor activity of the DSF/copper (DSF/Cu) complex has been identified. Its anti-multiple myeloma activity, however, has barely been investigated. In the present study, our results demonstrated that...

Full description

Bibliographic Details
Main Authors: Yaqi Xu, Qian Zhou, Xiaoli Feng, Yibo Dai, Yang Jiang, Wen Jiang, Xiaoli Liu, Xiangling Xing, Yongjing Wang, Yihong Ni, Chengyun Zheng
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Disulfiram
Myeloma
Apoptosis
JNK
Drug repurposing
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220302390

Internet

http://www.sciencedirect.com/science/article/pii/S0753332220302390

Similar Items