Phosphorylation Modulates Catalytic Activity of Mycobacterial Sirtuins

Phosphorylation Modulates Catalytic Activity of Mycobacterial Sirtuins

Sirtuins are NAD+ dependent deacetylases involved in the regulation of diverse cellular processes and are conserved throughout phylogeny. Here we report about in vitro transphosphorylation of the only NAD+ dependent deacetylase (mDAC) present in the genome of Mycobacterium tuberculosis by eukaryotic...

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Bibliographic Details
Main Authors: Ghanshyam Singh Yadav, Sandeep Kaur Ravala, Neha eMalhotra, Pradip K Chakraborti
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Microbiology
Subjects:
Protein phosphorylation
SIRTUIN
Site-directed mutagenesis
enzyme kinetics
Eukaryotic-type serine/threonine kinases
NAD+-dependent deacetylase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00677/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00677/full

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