Regulation of IL-6 Secretion by Astrocytes via TLR4 in the Fragile X Mouse Model

Regulation of IL-6 Secretion by Astrocytes via TLR4 in the Fragile X Mouse Model

Fragile X syndrome (FXS) is identified by abnormal dendrite morphology and altered synaptic protein expression. Astrocyte secreted factors such as Tenascin C (TNC), may contribute to the synaptic changes, including maturation of the synapse. TNC is a known endogenous ligand of toll-like receptor 4 (...

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Bibliographic Details
Main Authors: Victoria Krasovska, Laurie C. Doering
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
astrocyte
development
fragile X syndrome
Tenascin C
TLR4
IL-6
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00272/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00272/full

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