Virulence Vs. Immunomodulation: Roles of the Paracoccin Chitinase and Carbohydrate-Binding Sites in Paracoccidioides brasiliensis Infection

Virulence Vs. Immunomodulation: Roles of the Paracoccin Chitinase and Carbohydrate-Binding Sites in Paracoccidioides brasiliensis Infection

Paracoccin (PCN) is a bifunctional protein primarily present in the cell wall of Paracoccidioides brasiliensis, a human pathogenic dimorphic fungus. PCN has one chitinase region and four potential lectin sites and acts as both a fungal virulence factor and an immunomodulator of the host response. Th...

Full description

Bibliographic Details
Main Authors: Nayla de Souza Pitangui, Fabrício Freitas Fernandes, Relber Aguiar Gonçales, Maria Cristina Roque-Barreira
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
fungal chitinases
paracoccin
virulence factor
immunomodulatory agent
chitinase site
lectin site
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.700797/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.700797/full

Similar Items