Mechanism and Role of SOX2 Repression in Seminoma: Relevance to Human Germline Specification

Mechanism and Role of SOX2 Repression in Seminoma: Relevance to Human Germline Specification

Human male germ cell tumors (GCTs) are derived from primordial germ cells (PGCs). The master pluripotency regulator and neuroectodermal lineage effector transcription factor SOX2 is repressed in PGCs and the seminoma (SEM) subset of GCTs. The mechanism of SOX2 repression and its significance to GC a...

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Bibliographic Details
Main Authors: Ritu Kushwaha, Nirmala Jagadish, Manjunath Kustagi, Geetu Mendiratta, Marco Seandel, Rekha Soni, James E. Korkola, Venkata Thodima, Andrea Califano, George J. Bosl, R.S.K. Chaganti
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111630008X

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http://www.sciencedirect.com/science/article/pii/S221367111630008X

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