[18F]fallypride-PET/CT Analysis of the Dopamine D2/D3 Receptor in the Hemiparkinsonian Rat Brain Following Intrastriatal Botulinum Neurotoxin A Injection

[18F]fallypride-PET/CT Analysis of the Dopamine D2/D3 Receptor in the Hemiparkinsonian Rat Brain Following Intrastriatal Botulinum Neurotoxin A Injection

Intrastriatal injection of botulinum neurotoxin A (BoNT-A) results in improved motor behavior of hemiparkinsonian (hemi-PD) rats, an animal model for Parkinson’s disease. The caudate–putamen (CPu), as the main input nucleus of the basal ganglia loop, is fundamentally involved in motor function and d...

Full description

Bibliographic Details
Main Authors: Teresa Mann, Jens Kurth, Alexander Hawlitschka, Jan Stenzel, Tobias Lindner, Stefan Polei, Alexander Hohn, Bernd J. Krause, Andreas Wree
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
D2/D3 receptors
hemiparkinsonian rat model
Botulinum neurotoxin A
basal ganglia
striatum
Parkinson’s disease
small animal imaging
PET/CT
[18F]fallypride
MRI
Online Access:http://www.mdpi.com/1420-3049/23/3/587

Internet

http://www.mdpi.com/1420-3049/23/3/587

Similar Items