New Macrocyclic Amines Showing Activity as HIV Entry Inhibitors Against Wild Type and Multi-Drug Resistant Viruses

New Macrocyclic Amines Showing Activity as HIV Entry Inhibitors Against Wild Type and Multi-Drug Resistant Viruses

Considering as a lead molecule the chemokine CXCR4 receptor antagonist AMD-3100, which shows significant anti-HIV activity in vitro and in vivo, we investigated a series of structurally related macrocyclic polyamines incorporating o,o’-phenanthroline or 2,2’-bipyridyl scaffolds as potential antivira...

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Bibliographic Details
Main Authors: Massimo Galli, Cecilia Cabrera, Javier Martinez-Picado, Claudiu T. Supuran, Lidia Ruiz, Antonio Bianchi, Elisabetta Bulgheroni, Andrea Bencini, Stefania Ferramosca, Ottavia Viganò, Stefano Rusconi, Francesca Sirianni, Mirko Lo Cicero
Format: Article
Language:English
Published: MDPI AG 2009-05-01
Series:Molecules
Subjects:
HIV-1
co-receptors
CXCR4
macrocyclic polyamines
Online Access:http://www.mdpi.com/1420-3049/14/5/1927/

Internet

http://www.mdpi.com/1420-3049/14/5/1927/

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