The effect of strand bias in Illumina short-read sequencing data

<p>Abstract</p> <p>Background</p> <p>When using Illumina high throughput short read data, sometimes the genotype inferred from the positive strand and negative strand are significantly different, with one homozygous and the other heterozygous. This phenomenon is known a...

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Bibliographic Details
Main Authors: Guo Yan, Li Jiang, Li Chung-I, Long Jirong, Samuels David C, Shyr Yu
Format: Article
Language:English
Published: BMC 2012-11-01
Series:BMC Genomics
Subjects:
Online Access:http://www.biomedcentral.com/1471-2164/13/666