Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain

Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain

Konjac ceramide (kCer) is a plant-type ceramide composed of various long-chain bases and α-hydroxyl fatty acids. The presence of d4t,8t-sphingadienine is essential for semaphorin 3A (Sema3A)-like activity. Herein, we examined the three neuropilin 1 (Nrp1) domains (a1a2, b1b2, or c), and fou...

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Bibliographic Details
Main Authors: Seigo Usuki, Yoshiaki Yasutake, Noriko Tamura, Tomohiro Tamura, Kunikazu Tanji, Takashi Saitoh, Yuta Murai, Daisuke Mikami, Kohei Yuyama, Kenji Monde, Katsuyuki Mukai, Yasuyuki Igarashi
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
ceramide
konjac
semaphorin3a
neurite outgrowth
neuropilin 1
endoglycoceramidase
sphingadienine
Online Access:https://www.mdpi.com/2073-4409/9/2/517

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https://www.mdpi.com/2073-4409/9/2/517

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