Inhibition of cardiac PERK signaling promotes peripartum cardiac dysfunction

Abstract Peripartum cardiomyopathy (PPCM) is a life-threatening heart failure occurring in the peripartum period. Although mal-angiogenesis, induced by the 16-kDa N-terminal prolactin fragment (16 K PRL), is involved in the pathogenesis, the effect of full-length prolactin (23 K PRL) is poorly under...

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Bibliographic Details
Main Authors: Takashi Shimizu, Akashi Taguchi, Yoshiki Higashijima, Yasuharu Kanki, Ryo Nakaki, Yoshihiro Urade, Youichiro Wada
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-98344-7