Insights into the molecular mechanism of allostery in Hsp70s

Hsp70s chaperone an amazing number and variety of cellular protein folding processes. Key to their versatility is the recognition of a short degenerate sequence motif, present in practically all polypeptides, and a bidirectional allosteric intramolecular regulation mechanism linking their N-terminal...

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Bibliographic Details
Main Authors: Matthias Peter Mayer, Roman eKityk
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmolb.2015.00058/full