Identification of a Selective RelA Inhibitor Based on DSE-FRET Screening Methods

Identification of a Selective RelA Inhibitor Based on DSE-FRET Screening Methods

Nuclear factor-κB (NF-κB) is an important transcription factor involved in various biological functions, including tumorigenesis. Hence, NF-κB has attracted attention as a target factor for cancer treatment, leading to the development of several inhibitors. However, existing NF-κB inhibitors do not...

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Bibliographic Details
Main Authors: Yoshitomo Shiroma, Go Fujita, Takuya Yamamoto, Ryou-u Takahashi, Ashutosh Kumar, Kam Y. J. Zhang, Akihiro Ito, Hiroyuki Osada, Minoru Yoshida, Hidetoshi Tahara
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
NF-κB
DNA-binding protein
drug discovery
high-throughput screening
Online Access:https://www.mdpi.com/1422-0067/21/23/9150

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https://www.mdpi.com/1422-0067/21/23/9150

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