RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM

RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM

Abstract Background Amyotrophic lateral sclerosis (ALS) is an adult-onset, fatal neurodegenerative disease characterized by progressive loss of upper and lower motor neurons. While pathogenic mutations in the DNA/RNA-binding protein Matrin-3 (MATR3) are linked to ALS and distal myopathy, the molecul...

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Bibliographic Details
Main Authors: Nandini Ramesh, Sukhleen Kour, Eric N. Anderson, Dhivyaa Rajasundaram, Udai Bhan Pandey
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Acta Neuropathologica Communications
Subjects:
ALS
Myopathy
Matrin-3
hnRNPM
RNA-binding proteins
Drosophila
Online Access:http://link.springer.com/article/10.1186/s40478-020-01021-5

Internet

http://link.springer.com/article/10.1186/s40478-020-01021-5

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