Effects of Detergent on α-Synuclein Structure. A Native MS-Ion Mobility Study

Effects of Detergent on α-Synuclein Structure. A Native MS-Ion Mobility Study

The intrinsically disordered protein α-synuclein plays a major role in Parkinson’s disease. The protein can oligomerize resulting in the formation of various aggregated species in neuronal cells, leading to neurodegeneration. The interaction of α-synuclein with biological cell membranes plays an imp...

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Bibliographic Details
Main Authors: Rani Moons, Renate van der Wekken-de Bruijne, Stuart Maudsley, Filip Lemière, Anne-Marie Lambeir, Frank Sobott
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
ion mobility
mass spectrometry
α-synuclein
intrinsically disordered protein
detergent micelles
membrane interaction
Online Access:https://www.mdpi.com/1422-0067/21/21/7884

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https://www.mdpi.com/1422-0067/21/21/7884

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