Neuronal ensemble-specific DNA methylation strengthens engram stability

Memories are encoded within neuronal ensembles activated during learning. Here the authors show that DNA methylation within neuronal ensembles contributes to the stability of the memory trace, and increases the likelihood of neuronal ensemble reactivation during retrieval.

Bibliographic Details
Main Authors: Kubra Gulmez Karaca, Janina Kupke, David V. C. Brito, Benjamin Zeuch, Christian Thome, Dieter Weichenhan, Pavlo Lutsik, Christoph Plass, Ana M. M. Oliveira
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14498-4