Dysregulation of the hypothalamus-pituitary-adrenal axis predicts some aspects of the behavioral response to chronic fluoxetine: association with hippocampal cell proliferation

Dysregulation of the hypothalamus-pituitary-adrenal axis predicts some aspects of the behavioral response to chronic fluoxetine: association with hippocampal cell proliferation

In depressed patients, antidepressant resistance has been associated with dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis but the underlying mechanisms are poorly understood. The scope of this study was to try to create HPA-related antidepressant resistance in mice and to investigate...

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Bibliographic Details
Main Authors: Wahid eKhemissi, Rai Khalid eFAROOQ, Anne Marie eLe Guisquet, Mohsen eSakly, Catherine eBelzung
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Corticosterone
Fluoxetine
Hippocampal neurogenesis
Antidepressant resistance
unpredictable chronic mild stress
dexamethazone suppression
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00340/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00340/full

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