p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino

p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino

Summary: Many long noncoding RNA (lncRNA) genes exist near cancer-associated loci, yet evidence connecting lncRNA functions to recurrent genetic alterations in cancer are lacking. Here, we report that DINO, the lncRNA transcribed from the cancer-associated DINO/CDKN1A locus, suppresses tumor formati...

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Bibliographic Details
Main Authors: Christina B. Marney, Erik S. Anderson, Mutayyaba Adnan, Kai-Lin Peng, Ya Hu, Nils Weinhold, Adam M. Schmitt
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports
Subjects:
DINO
long noncoding RNA
p53
tumor suppression
cancer
DNA methylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721007051

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721007051

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