Levodopa-induced motor complications are associated with alterations of glutamate receptors in Parkinson's disease

Glutamate receptors were studied in the brains of controls and Parkinson's disease (PD) patients, of which 10 of 14 developed motor complications (dyskinesias and/or wearing-off) following levodopa therapy. 125I-RTI binding to the dopamine transporter and dopamine concentrations show comparable...

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Bibliographic Details
Main Authors: Frédéric Calon, Ali H Rajput, Oleh Hornykiewicz, Paul J Bédard, Thérèse Di Paolo
Format: Article
Language:English
Published: Elsevier 2003-12-01
Series:Neurobiology of Disease
Subjects:
NR1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103001463