A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division
Owa and Dynlacht employ an auxin-inducible degron system to achieve acute degradation of CENP-E. As a result, the authors reveal a kinetochore-independent role for CENP-E that removes PCM1 from centrosomes in interphase, with implications in microcephaly.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-01861-4 |