Multi‐Arm PEG/Peptidomimetic Conjugate Inhibitors of DR6/APP Interaction Block Hematogenous Tumor Cell Extravasation

Multi‐Arm PEG/Peptidomimetic Conjugate Inhibitors of DR6/APP Interaction Block Hematogenous Tumor Cell Extravasation

Abstract The binding of amyloid precursor protein (APP) expressed on tumor cells to death receptor 6 (DR6) could initiate the necroptosis pathway, which leads to necroptotic cell death of vascular endothelial cells (ECs) and results in tumor cells (TCs) extravasation and metastasis. This study repor...

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Bibliographic Details
Main Authors: Liting Wang, Qing Shen, Hongze Liao, Hao Fu, Qi Wang, Jian Yu, Wei Zhang, Chuanrong Chen, Yang Dong, Xupeng Yang, Qianqian Guo, Jiali Zhang, Jian Zhang, Houwen Lin, Yourong Duan
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Advanced Science
Subjects:
anti‐hematogenous metastatic activities
polymer–peptidomimetic conjugates
protein–protein interactions
structure‐based drug design
Online Access:https://doi.org/10.1002/advs.202003558

Internet

https://doi.org/10.1002/advs.202003558

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