Dietary α-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells

Dietary α-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells

Fatty acid synthetase (FAS) is overexpressed in various tumor tissues, and its inhibition and/or malonyl-CoA accumulation have been correlated to apoptosis of tumor cells. It is widely recognized that both ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) depress FAS expression in liver, although epid...

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Bibliographic Details
Main Authors: A. Vecchini, V. Ceccarelli, F. Susta, P. Caligiana, P. Orvietani, L. Binaglia, G. Nocentini, C. Riccardi, G. Calviello, P. Palozza, N. Maggiano, P. Di Nardo
Format: Article
Language:English
Published: Elsevier 2004-02-01
Series:Journal of Lipid Research
Subjects:
cyclooxygenase-2
polyunsaturated fatty acids
sterol regulatory element binding protein 1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520319039

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http://www.sciencedirect.com/science/article/pii/S0022227520319039

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