THE EFFECTS OF GABA-ERGIC DRUGS ON NALOXONE-PRECIPITATED WITHDRAWAL SIGNS IN CHRONICALLYMORPHINE-TREATED MICE

THE EFFECTS OF GABA-ERGIC DRUGS ON NALOXONE-PRECIPITATED WITHDRAWAL SIGNS IN CHRONICALLYMORPHINE-TREATED MICE

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1) Chronic administration of morphine hydrochloride in the drinking water of mice induced physical dependence. Jumping and diarrhea, two signs of withdrawal, were produced by intraperitoneal (IP) injection of naloxone. 2) Baclofen, bicuculline and picrotoxin decreased the number of mice's jumpi...

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Main Authors: Ali Mahfouzi,  Mohammad Reza Zarrindast
Format: Article
Language:English
Published: Tehran University of Medical Sciences 1994-06-01
Series:Acta Medica Iranica
Online Access:https://acta.tums.ac.ir/index.php/acta/article/view/240
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spelling doaj-bcafba134f1a4cce9d49e383eb2027a32020-11-25T03:21:42ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96941994-06-01321-2THE EFFECTS OF GABA-ERGIC DRUGS ON NALOXONE-PRECIPITATED WITHDRAWAL SIGNS IN CHRONICALLYMORPHINE-TREATED MICE Ali Mahfouzi0  Mohammad Reza Zarrindast1 1) Chronic administration of morphine hydrochloride in the drinking water of mice induced physical dependence. Jumping and diarrhea, two signs of withdrawal, were produced by intraperitoneal (IP) injection of naloxone. 2) Baclofen, bicuculline and picrotoxin decreased the number of mice's jumping episodes and frequency of diarrhea. 3) Muscimol decreased jumping but not diarrhea. 4) The data indicate that GABA-Ergic system is possibly involved in the morphine physical dependence, but further studies are required to elucidate the roles of GABA-A or GABA-B receptor sites in physical dependence.https://acta.tums.ac.ir/index.php/acta/article/view/240
collection DOAJ
language English
format Article
sources DOAJ
author Ali Mahfouzi
 Mohammad Reza Zarrindast
spellingShingle Ali Mahfouzi
 Mohammad Reza Zarrindast
THE EFFECTS OF GABA-ERGIC DRUGS ON NALOXONE-PRECIPITATED WITHDRAWAL SIGNS IN CHRONICALLYMORPHINE-TREATED MICE
Acta Medica Iranica
author_facet Ali Mahfouzi
 Mohammad Reza Zarrindast
author_sort Ali Mahfouzi
title THE EFFECTS OF GABA-ERGIC DRUGS ON NALOXONE-PRECIPITATED WITHDRAWAL SIGNS IN CHRONICALLYMORPHINE-TREATED MICE
title_short THE EFFECTS OF GABA-ERGIC DRUGS ON NALOXONE-PRECIPITATED WITHDRAWAL SIGNS IN CHRONICALLYMORPHINE-TREATED MICE
title_full THE EFFECTS OF GABA-ERGIC DRUGS ON NALOXONE-PRECIPITATED WITHDRAWAL SIGNS IN CHRONICALLYMORPHINE-TREATED MICE
title_fullStr THE EFFECTS OF GABA-ERGIC DRUGS ON NALOXONE-PRECIPITATED WITHDRAWAL SIGNS IN CHRONICALLYMORPHINE-TREATED MICE
title_full_unstemmed THE EFFECTS OF GABA-ERGIC DRUGS ON NALOXONE-PRECIPITATED WITHDRAWAL SIGNS IN CHRONICALLYMORPHINE-TREATED MICE
title_sort effects of gaba-ergic drugs on naloxone-precipitated withdrawal signs in chronicallymorphine-treated mice
publisher Tehran University of Medical Sciences
series Acta Medica Iranica
issn 0044-6025
1735-9694
publishDate 1994-06-01
description 1) Chronic administration of morphine hydrochloride in the drinking water of mice induced physical dependence. Jumping and diarrhea, two signs of withdrawal, were produced by intraperitoneal (IP) injection of naloxone. 2) Baclofen, bicuculline and picrotoxin decreased the number of mice's jumping episodes and frequency of diarrhea. 3) Muscimol decreased jumping but not diarrhea. 4) The data indicate that GABA-Ergic system is possibly involved in the morphine physical dependence, but further studies are required to elucidate the roles of GABA-A or GABA-B receptor sites in physical dependence.
url https://acta.tums.ac.ir/index.php/acta/article/view/240
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AT mohammadrezazarrindast theeffectsofgabaergicdrugsonnaloxoneprecipitatedwithdrawalsignsinchronicallymorphinetreatedmice
AT alimahfouzi effectsofgabaergicdrugsonnaloxoneprecipitatedwithdrawalsignsinchronicallymorphinetreatedmice
AT mohammadrezazarrindast effectsofgabaergicdrugsonnaloxoneprecipitatedwithdrawalsignsinchronicallymorphinetreatedmice
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