Evaluation of excess significance bias in animal studies of neurological diseases.

Evaluation of excess significance bias in animal studies of neurological diseases.

Animal studies generate valuable hypotheses that lead to the conduct of preventive or therapeutic clinical trials. We assessed whether there is evidence for excess statistical significance in results of animal studies on neurological disorders, suggesting biases. We used data from meta-analyses of i...

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Bibliographic Details
Main Authors: Konstantinos K Tsilidis, Orestis A Panagiotou, Emily S Sena, Eleni Aretouli, Evangelos Evangelou, David W Howells, Rustam Al-Shahi Salman, Malcolm R Macleod, John P A Ioannidis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-07-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23874156/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23874156/pdf/?tool=EBI

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