Transcriptional regulation of the beta-synuclein 5'-promoter metal response element by metal transcription factor-1.

The progression of many human neurodegenerative disorders is associated with an accumulation of alpha-synuclein. Alpha-synuclein belongs to the homologous synuclein family, which includes beta-synuclein. It has been proposed that beta-synuclein may be a natural regulator of alpha-synuclein. Therefor...

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Bibliographic Details
Main Authors: Patrick C McHugh, Josephine A Wright, David R Brown
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3046239?pdf=render